US Patent Issued to Massachusetts Institute of Technology on Aug. 12 for "Applications of engineered streptococcus canis Cas9 variants on single-base PAM targets" (North Carolina, Massachusetts Inventors)

ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,385,024, issued on Aug. 12, was assigned to Massachusetts Institute of Technology (Cambridge, Mass.).

"Applications of engineered streptococcus canis Cas9 variants on single-base PAM targets" was invented by Pranam Chatterjee (Durham, N.C.), Noah Michael Jakimo (Boston) and Joseph M. Jacobson (Newton, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Engineered Streptococcus canis Cas9 (ScCas9) variants include an ScCas9 protein with its PID being the PID amino acid composition of Streptococcus pyogenes Cas9 (SpCas9-NG, an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 in its amino acid sequence (Sc+), and an ScCas...