US Patent Issued to Massachusetts Institute of Technology on April 29 for "Methods for in vitro evolution of constructs derived from viruses" (Massachusetts Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,286,646, issued on April 29, was assigned to Massachusetts Institute of Technology (Cambridge, Mass.).

"Methods for in vitro evolution of constructs derived from viruses" was invented by Darrell J. Irvine (Arlington, Mass.), Ron Weiss (Newton, Mass.) and Yingzhong Li (Quincy, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure provides methods for an in vitro evolution technique to identify and characterize mutations in the non-structural genes of an alphavirus replicon that increase the strength and persistence of expression of the replicon genome. Also provided herein are in vivo methods for administering to an animal model a mutated al...