US Patent Issued to MABSOLVE on Dec. 16 for "Nucleic acids encoding modified immunoglobulin Fc regions" (British Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,442, issued on Dec. 16, was assigned to MABSOLVE Ltd. (Oxford, Great Britain).

"Nucleic acids encoding modified immunoglobulin Fc regions" was invented by Geoffrey Hale (Oxford, Great Britain) and Ian Wilkinson (Oxford, Great Britain).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are proteins comprising a variant IgG Fc region, wherein the proteins exhibit significantly reduced binding to human FcGammaRI when compared with a reference protein comprising the amino acid substitutions L234A/L235A/P329G. Also provided are compositions, methods of treatment and methods to reduce Fc-induced effector functions in a parent protein."

The patent was...