ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,447,152, issued on Oct. 21, was assigned to Lupin Ltd. (Mumbai, India).
"Pharmaceutical combination of PRMT5 inhibitors" was invented by Mandar Ramesh Bhonde (Pune, India), Venkata P. Palle (Pune, India) and Rajender Kumar Kamboj (Pune, India).
According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure relates to pharmaceutical combinations for treating and/or preventing cancer and methods and uses thereof. More particularly, provided are pharmaceutical combination comprising a PRMT5 Inhibitor and a cellular activity modulator selected from an EGFR inhibitor, a KRAS inhibitor, a KRAS-G12C inhibitor, a MEK inhibitor, a Bcl-2 inhibitor, a SOS1 inhibitor...