ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,522,837, issued on Jan. 13, was assigned to LONZA LTD (Visp, Switzerland).
"Promoter variants" was invented by Diethard Mattanovich (Vienna), Brigitte Gasser (Vienna) and Roland Prielhofer (Vienna).
According to the abstract* released by the U.S. Patent & Trademark Office: "An isolated and/or artificial pG1-x promoter, which is a functional variant of the carbon source regulatable pG1 promoter of Pichia pastoris identified by SEQ ID 1, which pG1-x promoter consists of or comprises at least a part of SEQ ID 1 with a length of at least 293 bp, characterized by the following promoter regions: a) at least one core regulatory region comprising the nucleotide sequences SEQ ID 2 and SEQ ID ...