ALEXANDRIA, Va., Jan. 28 -- United States Patent no. 12,534,493, issued on Jan. 27, was assigned to Liid Pharmaceuticals Inc. (Osaka, Japan).
"Bridged nucleoside and nucleotide" was invented by Yoshiyuki Hari (Tokushima, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "[Problem]Provision of bridged nucleosides and nucleotides that are less susceptible to decomposition by nuclease in vivo, have high binding affinity and specificity for the target mRNA, and can efficiently regulate the expression of specific genes.[Solving Means]A compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof:in the formula (I), Base shows a p...