ALEXANDRIA, Va., June 25 -- United States Patent no. 12,338,492, issued on June 24, was assigned to Life Technologies Corp. (Carlsbad, Calif.).
"Alternative nucleotide flows in sequencing-by-synthesis methods" was invented by Jonathan Schultz (Oxford, Mass.) and John Davidson (Guilford, Conn.).
According to the abstract* released by the U.S. Patent & Trademark Office: "A method of sequencing a polynucleotide strand can include providing the polynucleotide strand with a primer annealed thereto and a polymerase operably bound to the polynucleotide strand; successively exposing the polynucleotide strand to the flow of four different dNTPs according to a first predetermined ordering; and successively exposing the polynucleotide strand to the ...