US Patent Issued to Life Edit Therapeutics on March 18 for "DNA modifying enzymes and active fragments and variants thereof and methods of use" (North Carolina Inventors)

ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,718, issued on March 18, was assigned to Life Edit Therapeutics Inc. (Durham, N.C.).

"DNA modifying enzymes and active fragments and variants thereof and methods of use" was invented by Tyson D. Bowen (Morrisville, N.C.), Alexandra Briner Crawley (Cary, N.C.) and Tedd D. Elich (Durham, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compositions and methods comprising novel deaminase polypeptides for targeted editing of nucleic acids are provided. Compositions comprise deaminase polypeptides. Also provided are fusion proteins comprising a DNA-binding polypeptide and a deaminase of the invention. The fusion proteins include RNA-guided nucleases ...