US Patent Issued to LANOVA MEDICINES on March 11 for "CEACAM5-dependent 4-1BB-agonistic bispecific antibodies" (Chinese Inventors)

ALEXANDRIA, Va., March 12 -- United States Patent no. 12,247,081, issued on March 11, was assigned to LANOVA MEDICINES Ltd. (Shanghai).

"CEACAM5-dependent 4-1BB-agonistic bispecific antibodies" was invented by Runsheng Li (Shanghai), Wei Cao (Shanghai), Ying Qin Zang (Shanghai) and Wentao Huang (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are bispecific or multispecific antibodies that include an anti-CEACAM5 portion and one or more anti-4-1BB nanobodies whose agonist activity is dependent on the presence of the CEACAM5 antigen. Such bispecific or multispecific antibodies are safe, and are efficacious in treating cancer and have long-term protective immunological memory against tumors. M...