ALEXANDRIA, Va., Feb. 19 -- United States Patent no. 12,230,404, issued on Feb. 18, was assigned to Laboratory Corporation of America Holdings (Burlington, N.C.).

"Methods for indirect determination of reference intervals" was invented by Alexander L. Katayev (Graham, N.C.), Arren H. Fisher (Durham, N.C.), Dajie Luo (Cary, N.C.) and Mark Sharp (Gibsonville, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to methods for indirectly determining clinical laboratory reference intervals. In one aspect, a reference interval is determined using all measurements for a given analyte stored in a large existing database. In other aspects, a characteristic of a subject is used to select a refere...