ALEXANDRIA, Va., June 10 -- United States Patent no. 12,290,518, issued on May 6, was assigned to L.E.A.F. HOLDINGS GROUP LLC (Gulph Mills, Pa.).

"Gamma polyglutamated methotrexate and uses thereof" was invented by Clet Niyikiza (Gulph Mills, Pa.) and Victor Mandla Moyo (Ringoes, N.J.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure relates generally to gamma polyglutamated methotrexate compositions, including delivery vehicles such as liposomes containing the gamma polyglutamated methotrexate, and methods of making and using the gamma polyglutamated methotrexate compositions to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., inflammation and autoimmun...