ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,521,438, issued on Jan. 13, was assigned to Kymera Therapeutics Inc. (Watertown, Mass.).
"SMARCA degraders and uses thereof" was invented by Nan Ji (Arlington, Mass.), Yi Zhang (Belmont, Mass.), Michael D. Sintchak (Winchester, Mass.) and Paul R. Fleming (Lexington, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiqitination and/or degradation by compounds. The co...