US Patent Issued to KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION on Nov. 18 for "PD-1 variants having increased PD-L1 affinity" (South Korean Inventors)

ALEXANDRIA, Va., Nov. 18 -- United States Patent no. 12,473,349, issued on Nov. 18, was assigned to KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (Seoul, South Korea).

"PD-1 variants having increased PD-L1 affinity" was invented by Sang-Taek Jung (Seoul, South Korea) and Ji-Yeon Ha (Seoul, South Korea).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to PD-1 variants having minimal mutations for enhancing binding ability to PD-L1. The PD-1 variants of the present disclosure have fewer mutations than existing PD-1 and PD-1 variants and have significantly increased binding ability to PD-L1 compared to the existing variants, thereby solving the problem of immunogenicity. In addit...