ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,589, issued on March 25, was assigned to Kikkoman Corp. (Chiba, Japan).

"Glycated hemoglobin oxidase variant and method for measurement" was invented by Atsushi Ichiyanagi (Chiba, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is a glycated hemoglobin oxidase with small measurement error or without deviation of the measured value from the true value regarding a sample containing glycated abnormal hemoglobin. Provided are a glycated hemoglobin oxidase comprising an amino acid sequence in which the amino acid at the position corresponding to position 113, 109, 106, or 102 of the amino acid sequence of SEQ ID NO: 1 is substituted with a...