ALEXANDRIA, Va., Feb. 5 -- United States Patent no. 12,215,363, issued on Feb. 4, was assigned to KEYGENE N.V. (Wageningen, Netherlands).
"Balanced indels" was invented by Paul Bundock (Wageningen, Netherlands).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention pertains to the targeted alteration of a duplex DNA in a cell, whereby two site-specific nucleases generate an indel, such that the open reading frame is not altered after the second indel. The invention further pertains to the use of such nucleases for the targeted alteration of an open reading frame in duplex DNA and a kit of parts for use in a method of the invention. Using the method of the invention, novel plants were obtained having an ...