ALEXANDRIA, Va., June 16 -- United States Patent no. 12,304,966, issued on May 20, was assigned to KEMIJSKI INSTITUT (Ljubljana, Slovenia).
"Split superantigens and their use for immunotherapy" was invented by Roman Jerala (Ljubljana, Slovenia) and Anja Golob Urbanc (Kranj, Slovenia).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention refers to a split superantigen, divided into two fragments that by itself do not exhibit biologic activity, only upon dimerization they regain T cell activity. Scope of the invention is a screening method for detection of effective split superantigen designs, where split superantigen fragments are fused with coiled-coil forming peptides. The present invention relates to...