US Patent Issued to Karyopharm Therapeutics on Nov. 25 for "Process for preparing XPO1 inhibitors and intermediates for use in the preparation of XPO1 inhibitors" (Canadian, American Inventors)

ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,479,806, issued on Nov. 25, was assigned to Karyopharm Therapeutics Inc. (Newton, Mass.).

"Process for preparing XPO1 inhibitors and intermediates for use in the preparation of XPO1 inhibitors" was invented by Brian C. Austad (Tewksbury, Mass.) and David G. Roe (Rockwood, Canada).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides an improved process for preparation of the (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid (referred to as compound of the structural formula (III)), which is a useful key intermediate for the synthesis of Selinexor ((Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazo...