ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,480,948, issued on Nov. 25, was assigned to JILIN UNIVERSITY (Changchun, China).

"Ratiometric fluorescent probe for detecting aminopeptidase N, and preparation method and use thereof" was invented by Daqian Song (Changchun, China), Pinyi Ma (Changchun, China) and Dejiang Gao (Changchun, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is a ratiometric fluorescent probe for detecting aminopeptidase N, and a preparation method and use thereof. In the present disclosure, a Nile blue derivative is adopted as a fluorophore and alanyl is adopted as an identification unit to design and synthesize the ratiometric fluorescent probe NB-APN for detect...