ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,045, issued on Oct. 7, was assigned to JIANGSU CONCORD BIOTECHNOLOGY Co. LTD (Zhenjiang, China).

"Tyrosine kinase inhibitors and pharmaceutical application thereof" was invented by Huabiao Chen (Zhenjiang, China), Zhengyu Long (Zhenjiang, China) and Tao Li (Zhenjiang, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides a tyrosine kinase inhibitor having the general formula (I). R1 is C1-C6 alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, mono-substituted phenyl, poly-substituted phenyl, trifluoromethyl, 2,2,2-trifluoroethyl, CH3O(CH2)n-, R being methyl, ethyl, isopropyl, trifluoromethyl, 2,2,...