US Patent Issued to Jiangnan University on Nov. 25 for "Robustness of hydrolases by combining high-pressure molecular dynamics simulation and free energy calculation" (Chinese Inventors)

ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,482,539, issued on Nov. 25, was assigned to Jiangnan University (Wuxi, China).

"Robustness of hydrolases by combining high-pressure molecular dynamics simulation and free energy calculation" was invented by Xiaole Xia (Wuxi, China), Nan Zheng (Wuxi, China) and Zehua Zhang (Wuxi, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described is a method for screening hydrolases with improved robustness by combining high-pressure molecular dynamics simulation and free energy calculation. The disclosed methods belongs to the fields of computational chemistry, bioinformatics, genetic engineering, and protein engineering, where the above method constructs an...