US Patent Issued to Jazz Pharmaceuticals II on Oct. 14 for "Method of treating AML with PEGylated l-asparaginase" (French Inventor)

ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,441,992, issued on Oct. 14, was assigned to Jazz Pharmaceuticals II SAS (Lyons, France).

"Method of treating AML with PEGylated l-asparaginase" was invented by Thierry Abribat (Sainte Foy les Lyon, France).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed is L-asparagine aminohydrolase and polyethylene glycol conjugate. The polyethylene glycol has a molecular weight less than or equal to about 5000 Da and the protein is an L-asparaginase from Erwinia. The conjugate has a high level of in vitro activity and an unexpected increase in half-life in vivo. Methods of producing the conjugate and methods of using the conjugate in therapy in treatment of c...