US Patent Issued to Janssen Pharmaceuticals on Sept. 30 for "FimH mutant, compositions therewith and use thereof" (Dutch, German Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,428,449, issued on Sept. 30, was assigned to Janssen Pharmaceuticals Inc. (Titusville, N.J.).

"FimH mutant, compositions therewith and use thereof" was invented by Jan Grijpstra (Beesd, Netherlands), Eveline Marleen Weerdenburg (Uithoorn, Netherlands), Jeroen Geurtsen (Vleuten, Netherlands), Kellen Cristhina Fae (Mainz, Germany) and Louris Jakob Feitsma (Utrecht, Netherlands).

According to the abstract* released by the U.S. Patent & Trademark Office: "Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypep...