ALEXANDRIA, Va., June 10 -- United States Patent no. 12,290,563, issued on May 6, was assigned to Janssen Pharmaceuticals Inc. (Titusville, N.J.).
"Production of E. coli 018 bioconjugates" was invented by Jeroen Geurtsen (Vleuten, Netherlands), Marleen Eveline Weerdenburg (Uithoorn, Netherlands) and Pieter Jan Burghout (Pijnacker, Netherlands).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention pertains to host cells for producing a bioconjugate of an E. coli O18 antigen polysaccharide conjugated to a carrier protein. The host cells are characterized in that they comprise modified Wzy O-antigen polymerases with specific combinations of amino acid substitutions in one or more of positions 199, 377 and...