US Patent Issued to Janssen Pharmaceuticals on May 13 for "FimH mutants, compositions therewith and use thereof" (Dutch Inventors)

ALEXANDRIA, Va., June 12 -- United States Patent no. 12,297,238, issued on May 13, was assigned to Janssen Pharmaceuticals Inc. (Titusville, N.J.).

"FimH mutants, compositions therewith and use thereof" was invented by Jan Grijpstra (Beesd, Netherlands), Eveline Marleen Weerdenburg (Uithoorn, Netherlands), Jeroen Geurtsen (Vleuten, Netherlands), Kellen Cristhina Fae (Oegstgeest, Netherlands) and Louris Jakob Feitsma (Utrecht, Netherlands).

According to the abstract* released by the U.S. Patent & Trademark Office: "Polypeptides comprising a FimH lectin domain comprising at least one an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which c...