ALEXANDRIA, Va., June 25 -- United States Patent no. 12,338,243, issued on June 24, was assigned to JANSSEN PHARMACEUTICA NV (Beerse, Belgium).

"P2X7 modulators" was invented by Jose Ignacio Andres Gil (Madrid), Christa C. Chrovian (La Jolla, Calif.), Michael A. Letavic (San Diego), Jason C. Rech (San Diego), Dale A. Rudolph (San Diego) and Akinola Soyode-Johnson (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention is directed to compounds of Formula (I), which includes enantiomer and diasteromers thereof:The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope o...