US Patent Issued to Janssen Pharmaceutica on Feb. 25 for "Synthetic methods of preparing esketamine" (California Inventor)

ALEXANDRIA, Va., Feb. 26 -- United States Patent no. 12,234,200, issued on Feb. 25, was assigned to Janssen Pharmaceutica NV (Beerse, Belgium).

"Synthetic methods of preparing esketamine" was invented by Cheng Yi Chen (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention is directed to methods for the asymmetric synthesis of esketamine. The present invention is further directed to key intermediates in the asymmetric esketamine synthesis. In one embodiment, the invention is an asymmetric synthesis of esketamine comprising the conversion of (S)-2'-chloro-2-methoxy-3,4,5,6-5 tetrahydro-[1, 1'-biphenyl]-3-yl carbamate to (S)-2'-chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1'-biphe...