ALEXANDRIA, Va., June 16 -- United States Patent no. 12,303,483, issued on May 20, was assigned to Janssen Biotech Inc. (Horsham, Pa.).
"Lipase degradation resistant surfactants for use in large molecule therapeutic formulations" was invented by Steven LaBrenz (Exton, Pa.) and Patrick Stahl (Exton, Pa.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention is directed to pharmaceutical formulations of therapeutic proteins that comprise one or more polyethoxylated fatty alcohol (PFA) surfactants that are resistant to lipase mediated degradation. The present invention is also directed to methods of reducing aggregate and/or particulate formation in pharmaceutical formulations of therapeutic prote...