ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,493,035, issued on Dec. 9, was assigned to Ipsen Biopharm Ltd. (Wrexham, Great Britain).
"Cellular vamp cleavage assay" was invented by Bryony Gray (Wrexham, Great Britain), Verity Cadd (Wrexham, Great Britain) and Matthew Beard (Wrexham, Great Britain).
According to the abstract* released by the U.S. Patent & Trademark Office: "A method for determining cleavage of a VAMP by a clostridial neurotoxin in a cell that has been contacted with the clostridial neurotoxin under conditions suitable for clostridial neurotoxin activity, the method comprising contacting the cytoplasmic content of the cell with an antibody that binds to a resulting C-terminal product of such cleavage under suitabl...