US Patent Issued to Ionis Pharmaceuticals on May 6 for "Compositions and methods for modulating apolipoprotein (a) expression" (California Inventors)

ALEXANDRIA, Va., June 10 -- United States Patent no. 12,291,709, issued on May 6, was assigned to Ionis Pharmaceuticals Inc. (Carlsbad, Calif.).

"Compositions and methods for modulating apolipoprotein (a) expression" was invented by Thazha P. Prakash (Carlsbad, Calif.), Punit P. Seth (Carlsbad, Calif.), Eric E. Swayze (Encinitas, Calif.) and Mark J. Graham (San Clemente, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting apo(a) for ...