US Patent Issued to Ionis Pharmaceuticals on Dec. 23 for "Compounds and methods for modulating GFAP" (California Inventors)

ALEXANDRIA, Va., Dec. 23 -- United States Patent no. 12,502,402, issued on Dec. 23, was assigned to Ionis Pharmaceuticals Inc. (Carlsbad, Calif.).

"Compounds and methods for modulating GFAP" was invented by Berit Elissa Powers (Carlsbad, Calif.) and Frank Rigo (Carlsbad, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of GFAP RNA in a cell or subject, and in certain instances reducing the amount of GFAP in a cell or subject. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom or hallmark of a leukodystrophy. Such symptoms and hallmarks include motor del...