US Patent Issued to Ionis Pharmaceuticals on Aug. 12 for "Compounds and methods for reducing app expression" (California Inventor)

ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,384,814, issued on Aug. 12, was assigned to Ionis Pharmaceuticals Inc. (Carlsbad, Calif.).

"Compounds and methods for reducing app expression" was invented by Huynh-Hoa Bui (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of APP RNA in a cell or animal, and in certain instances reducing the amount of APP protein in a cell or animal. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom or hallmark of a neurodegenerative disease or disorder. Such symptoms and hallmarks include cognitive impairment,...