US Patent Issued to Ionis Pharmaceuticals on April 22 for "Compounds and methods for reducing prion expression" (California Inventors)

ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,305, issued on April 22, was assigned to Ionis Pharmaceuticals Inc. (Carlsbad, Calif.).

"Compounds and methods for reducing prion expression" was invented by Susan M. Freier (San Diego), Huynh-Hoa Bui (San Diego) and Hien Thuy Zhao (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of PRNP RNA in a cell or animal, and in certain instances reducing the amount of PrP protein in a cell or animal. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom or hallmark of a neurodegenerative disease. Such s...