ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,523,648, issued on Jan. 13, was assigned to ION Biosciences (San Marcos, Texas).
"Fluorescent indicators for calcium metal ion detection" was invented by Pedro Rogelio Escammilla (San Marcos, Texas), Jihyeon Lee (San Antonio) and Derek Scott Hernandez (Austin, Texas).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure describes compounds that can be used as Ca2+ chelators and fluorescent calcium indicators. The compounds incorporate a cyclopentyl group in the calcium binding portion of the Ca2+ fluorescent indicator. The indicators show substantially improved affinity for calcium ions in intracellular assays compared to other commercial...