ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,143, issued on Oct. 7, was assigned to INTERVET INC. (Rahway, N.J.).
"Caninized antibodies against canine CTLA-4" was invented by Mohamad Morsey (Omaha, Neb.), Yuanzheng Zhang (Somerset, N.J.) and Ian Tarpey (St. Ives, Great Britain).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides caninized murine antibodies against canine CTLA-4 that have specific sequences and a high binding affinity for canine CTLA-4. The present invention further provides epitopes of canine CTLA-4 for caninized murine antibodies against canine CTLA-4.5 The invention also relates to use of these antibodies in the treatment of cancer in canines and othe...