ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,448,417, issued on Oct. 21, was assigned to Intervet Inc. (Rahway, N.J.).
"Cryptosporidiosis vaccine" was invented by Markus Hendrikus Van Roosmalen (Berkel-Enschot, Netherlands) and Koen Gevers (Boxmeer, Netherlands).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention is based on the finding that incubating a Cryptosporidium gp40 protein with an aziridine, significantly increases its immunogenicity. When used as a vaccine, this allows a reduction of the dose, which improves economic feasibility and safety. Consequently the aziridine-treated gp40 can now be used as a safe and effective subunit-vaccine for humans or non-human-animals against Cryp...