ALEXANDRIA, Va., Dec. 23 -- United States Patent no. 12,502,426, issued on Dec. 23, was assigned to Intervet Inc. (Rahway, N.J.).
"Inactivated piscine orthoreovirus vaccine" was invented by Johanna Jacoba Elisabeth Bijlsma (Nijmegen, Netherlands), Sven Leininger (Bergen, Norway) and Stephane Villoing (Bergen, Norway).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention derives from the discovery that the immunogenicity of piscine orthoreovirus (PRV) can be significantly increased by inactivating the virus in a way different from the prior art: by incubation with an aziridine the vaccine potency against challenge infection by cohabitation is much improved over prior art approaches. This allowed the dev...