US Patent Issued to Integrated DNA Technologies on Oct. 28 for "Methods using novel CPF1 mutations that enhance the DNA cleavage activity of Acidaminococcus sp. CPF1" (Iowa Inventors)

ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,454,684, issued on Oct. 28, was assigned to Integrated DNA Technologies Inc. (Coralville, Iowa).

"Methods using novel CPF1 mutations that enhance the DNA cleavage activity of Acidaminococcus sp. CPF1" was invented by Liyang Zhang (Coralville, Iowa), Christopher Anthony Vakulskas (North Liberty, Iowa), Nicole Mary Bode (Oxford, Iowa), Michael Allen Collingwood (North Liberty, Iowa), Kristin Renee Beltz (Cedar Rapids, Iowa) and Mark Aaron Behlke (Coralville, Iowa).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure concerns polynucleotides and amino acids of Acidaminococcus sp. Cas12a (Cpf1) and methods for their use for genome editing in...