US Patent Issued to Institute of Advanced Sciences on April 29 for "Complex of botulinum neurotoxin E and its binding protein as a formulation with enhanced potency" (Massachusetts Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,285,469, issued on April 29, was assigned to Institute of Advanced Sciences Inc. (North Dartmouth, Mass.).

"Complex of botulinum neurotoxin E and its binding protein as a formulation with enhanced potency" was invented by Bal Ram Singh (Dartmouth, Mass.) and Raj Kumar (Dartmouth, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Methods of making the M or L complex of the botulinum neurotoxin E with its associated neurotoxin binding protein(s) (NBP), and methods of using to treat pain and wrinkles by injecting locally. Methods of making and isolating the L and M complex comprise a multi-step process of: providing a bacterial cultured media comprising ...