ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,517, issued on March 18, was assigned to INSTITUT CURIE (Paris) and CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS (Paris).
"Hook fusion protein for regulating the cellular trafficking of a target protein" was invented by Franck Perez (Paris), Zelia Gouveia (L'hay les Roses, France) and Gaelle Boncompain (Chatillon, France).
According to the abstract* released by the U.S. Patent & Trademark Office: "A hook fusion protein, which includes a hook domain and at least one cytoplasmic carboxyl endoplasmic reticulum (ER) retention signal and/or at least one cytoplasmic amino terminal endoplasmic reticulum (ER) retention signal; wherein the hook fusion protein is a soluble protein th...