ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,414,923, issued on Sept. 16, was assigned to INNOVATION ULSTER Ltd. (Antrim, Great Britain).
"Sonodynamic therapy" was invented by John Callan (Antrim, Great Britain), Anthony Mchale (Antrim, Great Britain) and Sian Farrell (Antrim, Great Britain).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides polymeric particles comprising a matrix of a biocompatible polymer and polyethylene imine, said matrix having incorporated therein an anionic or hydrophobic sonosensitiser and, optionally, an immunomodulatory agent and/or an imaging agent. Such particles find use in methods of sonodynamic therapy, in particular in methods of combined sonodyn...