ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,122, issued on Oct. 7, was assigned to ImmunityBio Inc. (San Diego).
"Fc-epsilon CAR" was invented by Laurent H. Boissel (San Diego), Hans G. Klingemann (San Diego), Abhijit Dandapat (San Diego) and Himani Chinnapen (San Diego).
According to the abstract* released by the U.S. Patent & Trademark Office: "Recombinant NK cells, and especially recombinant NK-92 cells express a chimeric antigen receptor (CAR) having an intracellular domain of FcEpsilonRIGamma. Notably, CAR constructs with an intracellular domain of FcEpsilonRIGamma had a substantially prolonged duration of expression and significantly extended cytotoxicity over time. The CAR may be expressed from RNA and DNA, preferabl...