US Patent Issued to Igor Beletsky on July 15 for "Method for producing NK cells with PD-1 knockout gene and trail or FAS-ligand overexpression" (Illinois Inventors)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,359,171, issued on July 15, was assigned to Igor Beletsky (Helsinki).

"Method for producing NK cells with PD-1 knockout gene and trail or FAS-ligand overexpression" was invented by Igor Petrovich Beletsky (Chicago).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to the field of medicine and genetic engineering, specifically to guide RNAs and DNA fragments and to cell selection methods, which can be used in CRISPR-Cas9 systems for producing lines of natural killer cells with a PD-1 knockout gene and increased production of TRAIL or Fas-ligand proteins. Methods are disclosed for producing modified lines of NK cells: with a PD-1 knockou...