ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,700, issued on March 18, was assigned to ID Pharma Co. Ltd. (Tokyo).
"Paramyxovirus vector" was invented by Koichi Saeki (Tokyo), Kohji Kusano (Tokyo), Hiroto Hara (Tokyo), Makoto Inoue (Tokyo) and Jitsutaro Kawaguchi (Tokyo).
According to the abstract* released by the U.S. Patent & Trademark Office: "An objective of the present invention is to provide an improved negative-strand RNA viral vector and a use thereof, the negative-strand RNA viral vector exhibiting transient high expression of genes loaded in the vector and enabling the rapid removal of the vector after said expression. It was discovered that by adding a micro-RNA target sequence to the NP, P, or L gene of a negati...