ALEXANDRIA, Va., March 26 -- United States Patent no. 12,257,300, issued on March 25, was assigned to HSF PHARMACEUTICALS S.A. (La Tour-de-Peilz, Switzerland).

"Replication-competent controlled alpha-herpesvirus vectors and uses therefore" was invented by Richard W Voellmy (La Tour-de-Peilz, Switzerland).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to replication-competent controlled herpesviruses whose transient replication in a desired inoculation site region of a subject can be activated by the delivery of an appropriate heat dose to the inoculation site region. In related recombinant viruses, activation requires delivery of a heat dose in the presence in the inoculation si...