ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,416,631, issued on Sept. 16, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).
"Immunoassay-based determination of in-solution binding kinetics" was invented by Uwe Dahl (Penzberg, Germany), Gregor Jordan (Groebenzell, Germany) and Roland Staack (Munich).
According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a method for the determination of the binding affinity of a binder and its ligand comprising the step of determining based on the result of an immunoassay the fraction of free binder in a sample comprising binder, ligand binder-ligand-complexes for at least two different binder:ligand ratios in the sample, and if the determined...