ALEXANDRIA, Va., Nov. 6 -- United States Patent no. 12,461,109, issued on Nov. 4, was assigned to Hoffmann-La Roche Inc..
"Vitro prediction of in vivo half-life" was invented by Thomas Emrich (Iffeldorf, Germany), Hubert Kettenberger (Munich), Tilman Schlothauer (Penzberg, Germany) and Angela Schoch (Munich).
According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a method for determining the presence of antibody-Fab-FcRn interaction in an antibody-Fc-FcRn complex influencing the in vivo half-life comprising the steps of a) determining the retention time of the antibody on an FcRn affinity chromatography column with a positive linear pH gradient elution in the presence of a first sodium chloride conc...