US Patent Issued to Hoffmann-La Roche on May 27 for "Targeted intracellular delivery of large nucleic acids" (German Inventors)

ALEXANDRIA, Va., June 17 -- United States Patent no. 12,312,386, issued on May 27, was assigned to Hoffmann-La Roche Inc. (Little Fall, N.J.).

"Targeted intracellular delivery of large nucleic acids" was invented by Ulrich Brinkmann (Weilheim, Germany) and Tobias Killian (Penzberg, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a composition for the targeted delivery of large nucleic acids to the nucleus of a eukaryotic cell comprising non-covalent complexes of histones in form of assembled nucleosomes, a large nucleic acid, a hapten, and a bispecific binder that has a first binding specificity to the hapten and a second binding specificity to a cell-surface target present on the e...