US Patent Issued to Hoffmann-La Roche on March 25 for "Oligonucleotides for inducing paternal UBE3A expression" (Danish, Swiss Inventors)

ALEXANDRIA, Va., March 26 -- United States Patent no. 12,259,380, issued on March 25, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).

"Oligonucleotides for inducing paternal UBE3A expression" was invented by Veronica Costa (Basel, Switzerland), Maj Hedtjarn (Horsholm, Denmark), Marius Hoener (Basel, Switzerland), Ravi Jagasia (Basel, Switzerland), Mads Aaboe Jensen (Horsholm, Denmark), Christoph Patsch (Basel, Switzerland), Lykke Pedersen (Horsholm, Denmark) and Soren Vestergaard Rasmussen (Horsholm, Denmark).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the pate...