ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,487,245, issued on Dec. 2, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).
"Antibody selection method" was invented by Hubert Kettenberger (Munich), Wolfgang Richter (Lorrach, Germany), Laurent Lariviere (Westendorf, Germany), Thomas Kraft (Munich) and Thomas Emrich (Iffeldorf, Germany).
According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a method for selecting an antibody with a systematic clearance in cynomolgus monkeys of less than 8 mL/kg/day comprising the steps of measuring the retention time of the antibody on performing an FcRn affinity chromatography with a positive linear pH gradient and on a heparin affinity chromatogr...