US Patent Issued to Hoffmann-La Roche on April 29 for "Direct affinity measurement of human IgG1 binding multimeric antigens" (German Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,287,335, issued on April 29, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).

"Direct affinity measurement of human IgG1 binding multimeric antigens" was invented by Michael Molhoj (Munich), Christian Gassner (Penzberg, Germany), Joerg Moelleken (Munich) and Manuel Endesfelder (Wessling, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a method for determining the binding affinity of the binding sites of a bivalent full length antibody of the human IgG1 subclass to a homo-multimeric antigen comprising the steps of i) incubating a mixture comprising the antibody and a polypeptide that is derived from lysine-gingipain o...